What are Exosomes?

Exosomes are not cells, they are little vesicles that bubble off of cells that we sometimes call extracellular vesicles (EVs).  In regenerative medicine, we sometimes use the exosomes that come off of stem cells as stem cell derived exosomes are packed with little messengers that signal growth, regeneration, repair, rebuilding, and more stem cell activity. 

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Science of Exosomes

 

Exosomes were first identified in 1981 by electron microscopy and scientist have spent many years unraveling their function.  Theses exosomes are also called extracellular vesicles or EVs and they are present in cells all over the body and serve many different functions.  One role that has been studied extensively is the role of communicating between cells with these exosomes packed with information in the form of proteins, lipids, genetic material and much more.  Exosomes are acellular vesicles that are able to transfer bioactive cargos that can signal changes in their environment. In medicine, we are discovering that exosomes have many therapeutic roles in immune therapy, vaccine development, cancer therapy, drug delivery, and regenerative medicine.

Exosome Therapies at Vivify

 

In regenerative medicine, we use mesenchymal stem cell derived exosomes that act as bioactive cargo carriers that can deliver many regenerative signals to promote healing, rebuilding, repair, and regeneration in the host tissue.  Exosomes contain mRNA which can enter the host cell and code for repair and regeneration.  These exosomes also contain growth factors and other cell signaling mediators that regulate a wide variety of physiologic and biologic processes.  Exosomes are a form of stem cell therapy without the stem cells.  They mediate cell migration, proliferation of cells, differentiation of cells, and development of the matrix surrounding the cells.  Exosomes are harvested from fetal stem cells in a laboratory, usually from umbilical cord tissue or placental tissue.  We can inject these harvested exosomes to use their cell signaling properties and their bioactive cargo to promote tissue growth, healing, repair, and regeneration. 

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