What is Human Growth Hormone (HGH)?

 

Human Growth Hormone (HGH), or somatotropin, is a peptide hormone that is secreted from a gland at the base of the brain called the pituitary.  That pituitary releases HGH as a result the actions of Growth Hormone Releasing Hormone (GHRH) & Growth Hormone Inhibiting Hormone (GHIH).  HGH is a building hormone that stimulates cell growth and provides the energy for cell growth.  Because growth hormone levels rise and fall in spurts throughout the day and night, blood measurements of growth hormone are meaningless.  Instead we measure growth hormone levels with a byproduct of HGH produced in the liver called Insulin like growth factor (IGF-1). 

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Can I take HGH?

 

Although in some cases physicians will prescribe growth hormone for documented deficiencies, in the United States, HGH has been banned for anti-aging and athletic performance. HGH is really only prescribed for specific circumstances. 

 

Fortunately, there are many peptide therapies that can be utilized to promote one’s own natural HGH secretion.  Secretagogues are molecules that bind to receptors in the hypothalamus of the brain or in the pituitary gland and stimulate the release of HGH.  We can accomplish this increased release of your natural growth hormone in 2 significant ways: stimulating the growth hormone secretagogue receptor (GHSR) or stimulating the growth hormone releasing receptor (GHRH).

What does HGH Do?

 

HGH is a very important hormone.  In children and adolescents it stimulates growth of bone and cartilage, increasing height until their growth plates close and they reach skeletal maturity.  Following puberty, there is an exponential decline in GH release after about 18-21 years of age, with levels falling about 14% per decade.  

 

HGH in adults is very important for building muscle, shedding fat, and maintaining strong bone density.  Because HGH is so important for muscle to fat ratio, we see a negative correlation of HGH release to BMI in adults as we age.  In an 18 month randomized placebo controlled trial, growth hormone therapy was shown to increase bone density, increase bone turnover, increase lean body mass, decrease body fat, and had very low incidence of side effects (Baum et al., 1996).  Growth Hormone was shown to promote more rapid healing with skin burns (Breederveld et al., 2012).  Cardiovascular benefits of growth hormone include decreasing LDL (the bad cholesterol), increasing HDL (the good cholesterol), and decreasing inflammation (lowers CRP, IL-6, & TNF-alpha) (Gazzaruso et al., 2014).  Growth hormone also helps to reverse the age related decline in certain immune cells, T & B cells.

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References:

 

  • Baum, H. B., Biller, B. M., Finkelstein, J. S., Cannistraro, K. B., Oppenheim, D. S., Schoenfeld, D. A., ... & Klibanski, A. (1996). Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency: a randomized, placebo-controlled trial. Annals of internal medicine, 125(11), 883-890.

  • Breederveld, R. S., & Tuinebreijer, W. E. (2012). Recombinant human growth hormone for treating burns and donor sites. Cochrane Database of Systematic Reviews, (12).

  • Gazzaruso, C., Gola, M., Karamouzis, I., Giubbini, R., & Giustina, A. (2014). Cardiovascular risk in adult patients with growth hormone (GH) deficiency and following substitution with GH—an update. The Journal of Clinical Endocrinology & Metabolism, 99(1), 18-29.

Growth Hormone Secretagogues & Growth Hormone Releasing Agonists.

As far as the category of GHSR agonists goes, ipamorelin is the peptide of choice because it strongly increases HGH but does not affect other hormones, such as stress hormones.  Most of the other secretagogues in this category also stimulate cortisol, acetylcholine, prolactin, and aldosterone; but ipamorelin is preferred for its selectivity to HGH release. 

 

In the category of GHRH agonists, CJC-1295 is often the peptide of choice for its effective release of HGH, its long acting effects, and its very low rate of side effects.  Both Ipamorelin and CJC-1295 are synergistic and often prescribed together for their anti-aging properties in promoting natural growth hormone release and combating the age related decline of HGH.

Where can I get CJC-1295 & Ipamorelin?

 

CJC-1295 & Ipamorelin are peptides only available by prescription.  Contact us today at Vivify Health & Wellness to see if you are a candidate for peptide therapies to promote your human growth hormone.