Prolotherapy is a non-surgical technique to promote healing and regeneration in tissues that dates back to the 1930s. Basically, prolotherapy involves injecting an irritant into the skin to promote an inflammatory cascade that results in the rebuilding of thicker and stronger connective tissue. Prolotherapy is sometimes called proliferation therapy or mesotherapy. The “prolo” in prolotherapy gets its name from the proliferation of connective tissue cells that comes after injecting an irritant into the tissue. This is an effective treatment for those who suffer from chronic injuries that have not recovered correctly or completely, prolotherapy is an option to sped up that recovery time and rebuild stronger connective tissue that can function better with less pain. Prolotherapy can be used to promote tissue repair in muscles, tendons, ligaments, joints and around nerves. It has been used effectively for many years to manage painful problems of the musculoskeletal system, including: tendinitis or tendinopathy, arthritis, ligament sprains, muscle strains, spinal disorders, neck pain, back pain, and nerve pain. These injections are often given a week apart for 2-4 weeks, then every 2 weeks for a month, and often provided with some sort of physical therapy. Prolotherapy can also be used in conjunction with other regenerative medicine interventions such as PRP.